城市元胞路网下自组织控制规则参数的整定

为解决城市信号自组织控制中,由相邻路口间各自最优通行效率冲突造成的路口群整体通行效率难以继续提升的问题,提出一种城市元胞路网下自组织控制规则参数的整定方法. 首先,利用城市路网元胞传输（CTM）模型模拟路网交通流动态状态信息;然后,基于元胞路网实时信息,以选定局域路网中各路口元胞的自组织控制规则参数为设计空间;最后,建立各路口相互协调下通行量最大化的目标函数,完成各路口自组织控制规则参数的整定. 仿真结果表明:在基于城市元胞路网实时信息条件的整定方法下,不仅解决了自组织控制中相邻路口间互相制约通行效率的问题,并且有效提高了自组织单元中所有路口的通行效率. 该方法为面向复杂城市路网的实时城市交通信号自组织控制系统提供可借鉴的智能化方法与工程化理论.     

迭代自组织数据法在数据关联中的研究与改进

针对目标密集环境下易出现的误关联问题,提出了ISODATA算法的解决方法.该算法将目标点迹的特征参量构成待分类的样本空间,构建了基于ISODATA算法的模型,利用航迹的历史状态数据进行关联运算,有效地解决了多目标密集环境下的误关联问题,分析了记忆步长与计算量和关联结果的关系.通过仿真研究说明了算法在目标密集环境下的有效性.     

离散杆战斗部相关技术研究进展

首先简单介绍了离散杆战斗部的发展现状,然后重点针对可控离散杆战斗部,从杆条完整性控制、杆条姿态控制、飞行规律、毁伤效应等四方面的相关技术研究进行综述;技术研究成果可为战斗部结构参数设计、指标优化设计、引战配合提供参考,对离散杆战斗部的进一步发展具有指导意义。     

一种鱼雷多目标跟踪数据关联方法

多目标跟踪是未来鱼雷发展的重要方向之一,数据关联是实现多目标跟踪的基本前提.鱼雷多目标跟踪的过程表现为一个动基座时变过程,本文利用鱼雷导航定位和航行姿态参数以及鱼雷检测到的目标信息,通过坐标变换实现观测空间配准,通过在统一时钟下实时计算采样周期实现观测时间配准.利用目标大地坐标系3D坐标和多普勒速度构造4D坐标系,以模糊归一化的4D欧氏距离作为关联法则,提出了一种适用于鱼雷多目标跟踪的数据关联方法,仿真试验证明了该方法能有效实现鱼雷多目标跟踪数据关联,具有一定的工程应用价值.     

基于改进粒子群算法的线缆路径规划方法研究

针对复杂机电产品布线路径规划过程中存在的效率较低、可应用性差等问题,提出一种改进粒子群算法,使用栅格法对布线空间进行划分,对障碍物建模并进行方向包围盒处理。为了避免算法在迭代过程中陷入局部最优,引入非线性逐渐递减的惯性权重与异步变化的学习因子,并且将贴壁约束加入到路径规划的过程中,保证线缆在敷设时路径的合理性。最后在仿真试验中,与标准粒子群算法进行对比,验证了改进后算法的合理性与可行性。     

分子轨道方法在有机反应机理中的应用

利用分子轨道理论直观解释了有机反应机理中所涉及到的立体化学、区域选择性以及对称性选择规律等有机化学中不易解释清楚的问题。相较于传统的"电子推动"方法,分子轨道方法更加直观,并能为有机反应机理的学习提供更深的理解。     

Circulating YKL-40 Level,but not CHI3L1 Gene Variants,Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease

YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease (PAD). Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes/haplotypes and YKL-40 levels for the health examination subjects (smallest p = 8.36 × 10⁻⁷ for rs4950928 and smallest p = 1.72 × 10⁻¹⁰ for haplotype TGG) and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD (p = 3.3 × 10⁻²³). Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease.     

The LBP Gene and Its Association with Resistance to Aeromonas hydrophila in Tilapia

Resistance to pathogens is important for the sustainability and profitability of food fish production. In immune-related genes, the lipopolysaccharide-binding protein (LBP) gene is an important mediator of the inflammatory reaction. We analyzed the cDNA and genomic structure of the LBP gene in tilapia. The full-length cDNA (1901 bp) of the gene contained a 1416 bp open reading frame, encoding 471 amino acid residues. Its genomic sequence was 5577 bp, comprising 15 exons and 14 introns. Under normal conditions, the gene was constitutively expressed in all examined tissues. The highest expression was detected in intestine and kidney. We examined the responses of the gene to challenges with two bacterial pathogens Streptcoccus agalactiae and Aeromonas hydrophila. The gene was significantly upregulated in kidney and spleen post-infection with S. agalactiae and A. hydrophila, respectively. However, the expression profiles of the gene after the challenge with the two pathogens were different. Furthermore, we identified three SNPs in the gene. There were significant associations (p < 0.05) of two of the three SNPs with the resistance to A. hydrophila, but not with the resistance to S. agalactiae or growth performance. These results suggest that the LBP gene is involved in the acute-phase immunologic response to the bacterial infections, and the responses to the two bacterial pathogens are different. The two SNPs associated with the resistance to A. hydrophila may be useful in the selection of tilapia resistant to A. hydrophila.     

The optimum synergistic effect of amphiphilic polymers and the stabilization mechanism of a crude oil emulsion

The amphiphilic polymers (APs) possess both thickening and emulsifying properties that were optimized by the combination of different APs. The properties and synergistic mechanisms of the combination system, consisting of HAP-L and HAP-S, were studied and optimized according to their proportion at various concentrations, temperatures, salinities, and shear rates. Furthermore, various methods were applied to study the emulsification properties of the combination system. The results show that the viscosity, salt resistance, temperature resistance, and shear resistance of the combination system are greatly improved. It is noteworthy that the combined system displays the optimized properties when the mass ratio of HAP-S and HAP-L is 3:2. Under that circumstance, the emulsions also turn to be more stable and display more uniform particle distribution. After combination, more hydrophobic groups participate in the intermolecular association, and the structure of the network is enhanced. Therefore, a combination of various APs can be used as an effective approach to improve the viscosity and emulsification capability of APs for oil recovery.     

代谢性疾病及治疗药物与肝癌的相关性研究进展

代谢性疾病与肝癌发病密切相关,其作用机制可能与体内胰岛素抵抗、高血糖、脂肪细胞因子分泌异常、内质网应激、肠道相关菌群失调、血脂异常等因素有关。研究表明治疗代谢性疾病的药物如二甲双胍和阿托伐他汀可以降低肝癌的发病和复发风险。本文就代谢性疾病及治疗药物与肝癌的相关性研究作一综述。